Endothelial Zinc Finger Protein Induced By Tumor Necrosis Factor Alpha (EZFIT)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TF_IIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.

By hybridization to a panel of somatic cell hybrids containing various deletions of chromosome 22, Aubry et al. (1992) mapped the genes encoding 2 zinc finger proteins to the short arm of chromosome 22 and 4 others to the 22q11.2 region. Hitherto, the short arms of acrocentric chromosomes were thought to encode only ribosomal RNA genes. The genes assigned to 22p were ZNF72 and ZNF73; those assigned to 22q11.2 were ZNF69, ZNF70, ZNF71, and ZNF74.