Gonadotropin Inducible Ovary Transcription Repressor 2 (GIOT2)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TF_IIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain. Bray et al. (1991) screened a placental genomic library at moderate stringency with a degenerate oligodeoxynucleotide probe designed to hybridize to the his/cys (H/C) link region between adjoining zinc fingers. Genomic clones were cross-hybridized with a set of 30 zinc finger-encoding cDNAs (KOX1-KOX30) isolated from a human T-cell cDNA library. KOX7 matched one of the genomic clones.Bray et al. (1991) mapped the ZNF44 gene to chromosome 16p11 by chromosomal in situ suppression hybridization with fluorescent probe detection.