By a combination of in situ chromosomal hybridization and somatic cell hybrid analysis, Rousseau-Merck et al. (1992) concluded that there are sequences hybridizing to the KOX2 probe at 2 loci, which they called ZNF11A (ZNF33A) and ZNF11B (ZNF33B), that map proximal and distal to a 10q11.2 breakpoint, respectively. They suggested that the 2 ZNF11 loci represent related sequences. Tunnacliffe et al. (1993) identified 2 related zinc finger gene clusters mapping to the pericentromeric region of chromosome 10. Cluster A contains ZNF11A (ZNF33A) and ZNF37A and maps to chromosome 10p11.2. Cluster B contains ZNF11B (ZNF33B) and ZNF37B and maps to chromosome 10q11.2. Southern blot analysis indicated that the 2 clusters evolved by duplication of an ancestral gene cluster before the divergence of the human and great ape lineages.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Zinc Finger Protein 33B (ZNF33B) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Zinc Finger Protein 33B (ZNF33B) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Zinc Finger Protein 33B (ZNF33B) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Zinc Finger Protein 33B (ZNF33B) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Zinc Finger Protein 33B (ZNF33B) | ELISA Kit Customized Service Offer |
- "Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p."Genome Res. 13:159-172(2003) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution."Nucleic Acids Res. 21:1409-1417(1993) [PubMed] [Europe PMC] [Abstract]
- "Multiple genes encoding zinc finger domains are expressed in human T cells."New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]