Zinc Finger Protein 193 (ZNF193)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TF_IIIA.

By direct cDNA hybridization to YACs from region 6p21.3, Lee et al. (1997) isolated ZNF193 from a cluster of zinc finger protein genes. All were members of the Kruppel family of transcriptional activators, containing a conserved C2H2 domain. Lee et al. (1997) cloned ZNF193 from an intestinal cDNA library. Northern blot analysis revealed that a 1.6-kb mRNA is expressed strongly in testis. Three larger mRNAs were detected at lower levels in other tissues. ZNF193 belongs to a subfamily of Kruppel proteins that have a 67-amino acid SCAN box and lack the A and B domains of the Kruppel-associated box (KRAB).