Zinc Finger Protein 133 (ZNF133)

Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. One abundant class of such transcriptional regulators resembles the Drosophila Kruppel segmentation gene product due to the presence of repeated Cys2-His2 (C2H2) zinc finger domains that are connected by conserved sequences, called H/C links.

ZNF133 protein contains 13 zinc finger domains preceeded by a putative degenerate finger domain, and both the KRAB A and B boxes. Northern blot analysis detected ZNF133 expression in all tissues examined.the KRAB domain of ZNF133 functions as a potent transcriptional repressor domain when fused to the yeast GAL4 DNA-binding domain.