≡

WW Domain Containing Oxidoreductase (WWOX)

[Edit]

FRA16D; FOR; HHCMA56; WOX1; WWOX v8; SDR41C1; Fragile site FRA16D oxidoreductase; Short Chain Dehydrogenase/Reductase Family 41C,Member 1

WW Domain Containing Oxidoreductase (WWOX)
CCC L823
HGNC 12799
MGI 1931237
PubMed 24369382
RGD 1309927
UniProt Q9NZC7
WWOX encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism.
The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WW Domain Containing Oxidoreductase (WWOX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WW Domain Containing Oxidoreductase (WWOX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WW Domain Containing Oxidoreductase (WWOX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WW Domain Containing Oxidoreductase (WWOX) CLIA Kit Customized Service Offer
n/a ELISA Kit for WW Domain Containing Oxidoreductase (WWOX) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WW Domain Containing Oxidoreductase (WWOX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WW Domain Containing Oxidoreductase (WWOX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WW Domain Containing Oxidoreductase (WWOX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WW Domain Containing Oxidoreductase (WWOX) CLIA Kit Customized Service Offer
n/a ELISA Kit for WW Domain Containing Oxidoreductase (WWOX) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WW Domain Containing Oxidoreductase (WWOX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WW Domain Containing Oxidoreductase (WWOX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WW Domain Containing Oxidoreductase (WWOX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WW Domain Containing Oxidoreductase (WWOX) CLIA Kit Customized Service Offer
n/a ELISA Kit for WW Domain Containing Oxidoreductase (WWOX) ELISA Kit Customized Service Offer
  1. "WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer."Cancer Res. 60:2140-2145(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells."Hum. Mol. Genet. 9:1651-1663(2000) [PubMed] [Europe PMC] [Abstract]
  3. "WWOX, the FRA16D gene, behaves as a suppressor of tumor growth."Cancer Res. 61:8068-8073(2001) [PubMed] [Europe PMC] [Abstract]
  4. "WWOX: a candidate tumor suppressor gene involved in multiple tumor types."Proc. Natl. Acad. Sci. U.S.A. 98:11417-11422(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "An opposing view on WWOX protein function as a tumor suppressor."Cancer Res. 63:8629-8633(2003) [PubMed] [Europe PMC] [Abstract]
  8. "JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis."J. Biol. Chem. 278:9195-9202(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma."Br. J. Cancer 91:753-759(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor."Cancer Res. 64:8256-8261(2004) [PubMed] [Europe PMC] [Abstract]
  11. "The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis."Clin. Cancer Res. 10:2459-2465(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Loss of WWOX expression in gastric carcinoma."Clin. Cancer Res. 10:3053-3058(2004) [PubMed] [Europe PMC] [Abstract]
  13. "WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins."Oncogene 23:5049-5055(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Functional association between Wwox tumor suppressor protein and p73, a p53 homolog."Proc. Natl. Acad. Sci. U.S.A. 101:4401-4406(2004) [PubMed] [Europe PMC] [Abstract]
  15. "WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function."Cancer Res. 65:6764-6772(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox."Cancer Res. 65:10514-10523(2005) [PubMed] [Europe PMC] [Abstract]
  17. "WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53."J. Biol. Chem. 280:43100-43108(2005) [PubMed] [Europe PMC] [Abstract]
  18. "WWOX gene restoration prevents lung cancer growth in vitro and in vivo."Proc. Natl. Acad. Sci. U.S.A. 102:15611-15616(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1."J. Biol. Chem. 284:16049-16059(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein."Oncogene 28:2569-2580(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  22. "A WWOX-binding molecule, transmembrane protein 207, is related to the invasiveness of gastric signet-ring cell carcinoma."Carcinogenesis 33:548-554(2012) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration."Orphanet J. Rare Dis. 9:12-12(2014) [PubMed] [Europe PMC] [Abstract]
  25. "WWOX-related encephalopathies: delineation of the phenotypical spectrum and emerging genotype-phenotype correlation." J. Med. Genet. 52:61-70(2015) [PubMed] [Europe PMC] [Abstract]
  26. "Solution structure of the second WW domain of WWOX."Submitted (FEB-2009) to the PDB data bank
  27. "Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma."Cancer Res. 62:2258-2260(2002) [PubMed] [Europe PMC] [Abstract]
  28. "The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation."Brain 137:411-419(2014) [PubMed] [Europe PMC] [Abstract]