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Wolf Hirschhorn Syndrome Candidate 2 (WHSC2)

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NELF-A; NELFA; P/OKcl.15; Negative elongation factor A

Wolf Hirschhorn Syndrome Candidate 2 (WHSC2)
CCC L828
HGNC 12768
MGI 1346098
PubMed 22957023
RGD 1305556
UniProt Q9H3P2
Wiki WHSC2
WHSC2 is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein.This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome.
The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. WHSC2 encodes the NELF-A subunit of the NELF complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wolf Hirschhorn Syndrome Candidate 2 (WHSC2) ELISA Kit Customized Service Offer
  1. "Comparative analysis of a novel gene from the Wolf-Hirschhorn/Pitt-Rogers-Danks syndrome critical region."Genomics 59:203-212(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular basis of T cell-mediated recognition of pancreatic cancer cells."Cancer Res. 61:2038-2046(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Stimulation of RNA polymerase II elongation by hepatitis delta antigen."Science 293:124-127(2001) [PubMed] [Europe PMC] [Abstract]
  7. "NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation."Cell 97:41-51(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Modulation of WHSC2 expression in human endothelial cells."FEBS Lett. 487:166-170(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Mapping the Wolf-Hirschhorn syndrome phenotype outside the currently accepted WHS critical region and defining a new critical region, WHSCR-2."Am. J. Hum. Genet. 72:590-597(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex."Mol. Cell. Biol. 23:1863-1873(2003) [PubMed] [Europe PMC] [Abstract]
  11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]