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Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1)

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NSD3; Nuclear SET domain-containing protein 3; Protein whistle; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; Histone-lysine N-methyltransferase NSD3

Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1)
CCC L829
HGNC 12767
MGI 2142581
PubMed 11549311
RGD 1308980
UniProt Q9BZ95
WHSC1L1 is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described.
The deduced 1,437-amino acid protein contains 2 PWWP domains involved in protein-protein interaction, 5 PHD-type zinc finger motifs found in chromatin-associated proteins, a SAC (SET-associated cys-rich) domain, a SET domain, and a C-terminal C5HCH domain. They also identified a variant, arising from alternative polyadenylation and exon splicing, that encodes a deduced 645-amino acid peptide. The short isoform contains a single PWWP domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wolf Hirschhorn Syndrome Candidate 1 Like Protein 1 (WHSC1L1) ELISA Kit Customized Service Offer
  1. "WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3."Genomics 76:5-8(2001) [PubMed] [Europe PMC] [Abstract]
  2. "NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines."Genomics 74:79-88(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15)."Blood 99:3857-3860(2002) [PubMed] [Europe PMC] [Abstract]
  7. "High-resolution genomic profiles of human lung cancer."Proc. Natl. Acad. Sci. U.S.A. 102:9625-9630(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity."Biochem. Biophys. Res. Commun. 345:318-323(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3."Mol. Cell. Biol. 31:2641-2652(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of second PWWP domain of WHSC1L1 protein."Submitted (DEC-2005) to the PDB data bank