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Oxidative Stress Responsive 1 (OXSR1)

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OSR1; Serine/threonine-protein kinase OSR1

Oxidative Stress Responsive 1 (OXSR1)
CCC L837
HGNC 8508
MGI 1917378
PubMed 20819979
RGD 1310466
UniProt O95747
Wiki OXSR1
OSR1 belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.
OXSR1 contains an N-terminal Ste20-like serine/threonine kinase domain and 2 C-terminal regions, designated PF1 and PF2, conserved with other members of the germinal center kinase (GCK) VI subfamily of Ste20 kinases, such as SPAK (STK39). At the end of the PF1 domain, OXSR1 has a putative caspase-3 (CASP3) cleavage site. Western blot analysis detected Oxsr1 at an apparent molecular mass of 58 kD in all mouse tissues examined except thymus. Cell fractionation and immunofluorescence analysis of HeLa cells showed that OXSR1 was distributed throughout the cell.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
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Assay Kits SEL837Hu ELISA Kit for Oxidative Stress Responsive 1 (OXSR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oxidative Stress Responsive 1 (OXSR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxidative Stress Responsive 1 (OXSR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxidative Stress Responsive 1 (OXSR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oxidative Stress Responsive 1 (OXSR1) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Oxidative Stress Responsive 1 (OXSR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Oxidative Stress Responsive 1 (OXSR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Oxidative Stress Responsive 1 (OXSR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Oxidative Stress Responsive 1 (OXSR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Oxidative Stress Responsive 1 (OXSR1) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3."J. Hum. Genet. 44:116-120(1999) [PubMed] [Europe PMC] [Abstract].
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  4. "Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily."J. Biol. Chem. 279:11129-11136(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1."Biochem. Biophys. Res. Commun. 340:535-543(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy."J. Proteomics 75:2236-2251(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]