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Origin Recognition Complex Subunit 6 Like Protein (ORC6L)

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ORC6

Origin Recognition Complex Subunit 6 Like Protein (ORC6L)
CCC L850
HGNC 17151
MGI 1929285
PubMed 15467761
RGD 1311437
UniProt Q9Y5N6
Wiki ORC6L
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.
ORC6L is a subunit of the ORC complex. It has been shown that this protein and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 6 Like Protein (ORC6L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 6 Like Protein (ORC6L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 6 Like Protein (ORC6L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 6 Like Protein (ORC6L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 6 Like Protein (ORC6L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 6 Like Protein (ORC6L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 6 Like Protein (ORC6L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 6 Like Protein (ORC6L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 6 Like Protein (ORC6L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 6 Like Protein (ORC6L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 6 Like Protein (ORC6L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 6 Like Protein (ORC6L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 6 Like Protein (ORC6L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 6 Like Protein (ORC6L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 6 Like Protein (ORC6L) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  4. "ATP-dependent assembly of the human origin recognition complex."J. Biol. Chem. 282:32370-32383(2007) [PubMed] [Europe PMC] [Abstract]
  5. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing."J. Biol. Chem. 287:15024-15033(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB."Proc. Natl. Acad. Sci. U.S.A. 108:7373-7378(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in the pre-replication complex cause Meier-Gorlin syndrome." Nat. Genet. 43:356-359(2011) [PubMed] [Europe PMC] [Abstract]