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Origin Recognition Complex Subunit 1 Like Protein (ORC1L)

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HSORC1; ORC1; PARC1; Replication Control Protein 1

Origin Recognition Complex Subunit 1 Like Protein (ORC1L)
CCC L851
HGNC 8487
MGI 1328337
PubMed 8884289
RGD 631435
UniProt Q13415
Wiki ORC1L
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC1L is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 1 Like Protein (ORC1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 1 Like Protein (ORC1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 1 Like Protein (ORC1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 1 Like Protein (ORC1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 1 Like Protein (ORC1L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 1 Like Protein (ORC1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 1 Like Protein (ORC1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 1 Like Protein (ORC1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 1 Like Protein (ORC1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 1 Like Protein (ORC1L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 1 Like Protein (ORC1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 1 Like Protein (ORC1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 1 Like Protein (ORC1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 1 Like Protein (ORC1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 1 Like Protein (ORC1L) ELISA Kit Customized Service Offer
  1. "Conserved initiator proteins in eukaryotes."Science 270:1667-1671(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase."Mol. Cell. Biol. 18:2758-2767(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein."J. Biol. Chem. 274:23027-23034(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1."J. Biol. Chem. 278:41528-41534(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle."J. Biol. Chem. 278:41535-41540(2003) [PubMed] [Europe PMC] [Abstract]
  7. "ATP-dependent assembly of the human origin recognition complex."J. Biol. Chem. 282:32370-32383(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation."Mol. Cell. Biol. 32:3107-3120(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome."Nat. Genet. 43:350-355(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Mutations in the pre-replication complex cause Meier-Gorlin syndrome." Nat. Genet. 43:356-359(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome." Nat. Genet. 43:360-364(2011) [PubMed] [Europe PMC] [Abstract]