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Origin Recognition Complex Subunit 2 Like Protein (ORC2L)

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ORC2

Origin Recognition Complex Subunit 2 Like Protein (ORC2L)
CCC L852
HGNC 8488
MGI 1328306
PubMed 8808289
RGD 1311844
UniProt Q13416
Wiki ORC2L
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.
ORC2L is a subunit of the ORC complex. This protein forms a core complex with ORC3L, -4L, and -5L. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 2 Like Protein (ORC2L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 2 Like Protein (ORC2L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 2 Like Protein (ORC2L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 2 Like Protein (ORC2L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 2 Like Protein (ORC2L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 2 Like Protein (ORC2L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 2 Like Protein (ORC2L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 2 Like Protein (ORC2L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 2 Like Protein (ORC2L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 2 Like Protein (ORC2L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 2 Like Protein (ORC2L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 2 Like Protein (ORC2L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 2 Like Protein (ORC2L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 2 Like Protein (ORC2L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 2 Like Protein (ORC2L) ELISA Kit Customized Service Offer
  1. "Conserved initiator proteins in eukaryotes."Science 270:1667-1671(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L."Genomics 31:119-122(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase."Nucleic Acids Res. 28:4769-4777(2000) [PubMed] [Europe PMC] [Abstract]
  6. "The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle."J. Biol. Chem. 278:41535-41540(2003) [PubMed] [Europe PMC] [Abstract]
  7. "ATP-dependent assembly of the human origin recognition complex."J. Biol. Chem. 282:32370-32383(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Orc2 protects ORCA from ubiquitin-mediated degradation."Cell Cycle 11:3578-3589(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing."J. Biol. Chem. 287:15024-15033(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation."Mol. Cell. Biol. 32:3107-3120(2012) [PubMed] [Europe PMC] [Abstract]
  14. "A role for DNA polymerase theta in the timing of DNA replication."Nat. Commun. 5:4285-4285(2014) [PubMed] [Europe PMC] [Abstract]