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Origin Recognition Complex Subunit 3 Like Protein (ORC3L)

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LAT; LATHEO; ORC3; Origin recognition complex subunit Latheo

Origin Recognition Complex Subunit 3 Like Protein (ORC3L)
CCC L853
HGNC 8489
MGI 1354944
PubMed 9829972
RGD 1308457
UniProt Q9UBD5
Wiki ORC3L
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.
ORC3L is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 3 Like Protein (ORC3L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 3 Like Protein (ORC3L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 3 Like Protein (ORC3L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 3 Like Protein (ORC3L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 3 Like Protein (ORC3L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 3 Like Protein (ORC3L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 3 Like Protein (ORC3L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 3 Like Protein (ORC3L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 3 Like Protein (ORC3L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 3 Like Protein (ORC3L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 3 Like Protein (ORC3L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 3 Like Protein (ORC3L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 3 Like Protein (ORC3L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 3 Like Protein (ORC3L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 3 Like Protein (ORC3L) ELISA Kit Customized Service Offer
  1. "Latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant."Neuron 23:45-54(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle."J. Biol. Chem. 278:41535-41540(2003) [PubMed] [Europe PMC] [Abstract]
  7. "ATP-dependent assembly of the human origin recognition complex."J. Biol. Chem. 282:32370-32383(2007) [PubMed] [Europe PMC] [Abstract]
  8. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing."J. Biol. Chem. 287:15024-15033(2012) [PubMed] [Europe PMC] [Abstract]