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Origin Recognition Complex Subunit 4 Like Protein (ORC4L)

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ORC4; ORC4P; HsORC4

Origin Recognition Complex Subunit 4 Like Protein (ORC4L)
CCC L854
HGNC 8490
MGI 1347043
PubMed 21497890
RGD 735212
UniProt O43929
Wiki ORC4L
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells.
ORC4L is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L. Three alternatively spliced transcript variants encoding the same protein have been reported.The predicted 436-amino acid human ORC4L protein, which they called HsORC4P, shares 29% sequence identity with yeast ORC4. Antibodies against ORC4L detected a 45-kD doublet on immunoblots of human cell lysates. Immunoprecipitation studies revealed that ORC4L associates with multiple cellular proteins, including ORC2L, in vivo.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 4 Like Protein (ORC4L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 4 Like Protein (ORC4L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 4 Like Protein (ORC4L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 4 Like Protein (ORC4L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 4 Like Protein (ORC4L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 4 Like Protein (ORC4L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 4 Like Protein (ORC4L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 4 Like Protein (ORC4L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 4 Like Protein (ORC4L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 4 Like Protein (ORC4L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Origin Recognition Complex Subunit 4 Like Protein (ORC4L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Origin Recognition Complex Subunit 4 Like Protein (ORC4L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Origin Recognition Complex Subunit 4 Like Protein (ORC4L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Origin Recognition Complex Subunit 4 Like Protein (ORC4L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Origin Recognition Complex Subunit 4 Like Protein (ORC4L) ELISA Kit Customized Service Offer
  1. "Identification of HsORC4, a member of the human origin of replication recognition complex."J. Biol. Chem. 272:28247-28251(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle."J. Biol. Chem. 278:41535-41540(2003) [PubMed] [Europe PMC] [Abstract]
  6. "ATP-dependent assembly of the human origin recognition complex."J. Biol. Chem. 282:32370-32383(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing."J. Biol. Chem. 287:15024-15033(2012) [PubMed] [Europe PMC] [Abstract]
  10. "A role for DNA polymerase theta in the timing of DNA replication."Nat. Commun. 5:4285-4285(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in the pre-replication complex cause Meier-Gorlin syndrome." Nat. Genet. 43:356-359(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome." Nat. Genet. 43:360-364(2011) [PubMed] [Europe PMC] [Abstract]