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Obg Like ATPase 1 (OLA1)

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GTPBP9; DOC45; GTP-binding protein 9; DNA damage-regulated overexpressed in cancer 45

Obg Like ATPase 1 (OLA1)
CCC L861
HGNC 28833
MGI 1914309
PubMed 24289923
RGD 1307982
UniProt Q9NTK5
Wiki OLA1
OLA1 binds and hydrolyzes ATP more efficiently than GTP and thus is a member of a new subclass of NTPases in the Obg family of GTPases.members of this protein family from different species also have ATPase activity and are not exclusively GTPases. one cause of the altered nucleotide specificity of this subclass of NTPases is a substitution of a hydrophobic amino acid for a glutamine in all members of the Obg family. They noted that the same substitution inactivates Ras-like GTPases.
The deduced 396-amino acid protein consists of an N-terminal G domain, flanked on either side by an inserted coiled-coil, and a C-terminal TGS domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL861Hu01 Recombinant Obg Like ATPase 1 (OLA1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Obg Like ATPase 1 (OLA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Obg Like ATPase 1 (OLA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Obg Like ATPase 1 (OLA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Obg Like ATPase 1 (OLA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Obg Like ATPase 1 (OLA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Obg Like ATPase 1 (OLA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Obg Like ATPase 1 (OLA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Obg Like ATPase 1 (OLA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Obg Like ATPase 1 (OLA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Obg Like ATPase 1 (OLA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Obg Like ATPase 1 (OLA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Obg Like ATPase 1 (OLA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Obg Like ATPase 1 (OLA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Obg Like ATPase 1 (OLA1) ELISA Kit Customized Service Offer
  1. "DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that is overexpressed in multiple human malignancies."Mol. Cancer Res. 8:57-66(2010) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins."J. Biol. Chem. 282:19928-19937(2007) [PubMed] [Europe PMC] [Abstract]
  9. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]