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U2AF Homology Motif Kinase 1 (UHMK1)

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KIS; Kist; P-CIP2; Kinase interacting with stathmin; PAM COOH-terminal interactor protein 2; Serine/threonine-protein kinase Kist

U2AF Homology Motif Kinase 1 (UHMK1)
CCC L889
HGNC 19683
MGI 1341908
PubMed 20573687
RGD 2968
UniProt Q8TAS1
Wiki UHMK1
UHMK1 is a kinase enzyme which phosphorylates the protein stathmin and has an RNA recognition motif of unknown function.
UHMK1 is highly expressed in the brain and has been genetically implicated in schizophrenia in two genetic studies. Mice with the gene encoding stathmin knocked out, so that they do not express this protein in the brain, show abnormal fear responses. This effect could be developed as an animal model for schizophrenia.UHMK1 also phosphorylates the CNS proteins myelin basic protein (MBP) and synapsin I so that genetic abnormalities in UHMK1 could contribute to the genetic cause of schizophrenia through several different brain pathways.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant U2AF Homology Motif Kinase 1 (UHMK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to U2AF Homology Motif Kinase 1 (UHMK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to U2AF Homology Motif Kinase 1 (UHMK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for U2AF Homology Motif Kinase 1 (UHMK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for U2AF Homology Motif Kinase 1 (UHMK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant U2AF Homology Motif Kinase 1 (UHMK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to U2AF Homology Motif Kinase 1 (UHMK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to U2AF Homology Motif Kinase 1 (UHMK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for U2AF Homology Motif Kinase 1 (UHMK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for U2AF Homology Motif Kinase 1 (UHMK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant U2AF Homology Motif Kinase 1 (UHMK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to U2AF Homology Motif Kinase 1 (UHMK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to U2AF Homology Motif Kinase 1 (UHMK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for U2AF Homology Motif Kinase 1 (UHMK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for U2AF Homology Motif Kinase 1 (UHMK1) ELISA Kit Customized Service Offer
  1. "Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human."Brain Res. Mol. Brain Res. 114:55-64(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase."J. Biol. Chem. 274:34646-34656(1999) [PubMed] [Europe PMC] [Abstract]
  6. "A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression."EMBO J. 21:3390-3401(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The CATS (FAM64A) protein is a substrate of the kinase interacting stathmin (KIS)."Biochim. Biophys. Acta 1833:1269-1279(2013) [PubMed] [Europe PMC] [Abstract]
  8. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]