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NGFI-A Binding Protein 2 (NAB2)

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MADER; EGR1 Binding Protein 2; Melanoma-associated delayed early response protein

NGFI-A Binding Protein 2 (NAB2)
CCC L900
HGNC 7627
MGI 107563
PubMed 8668170
RGD 1311712
UniProt Q15742
Wiki NAB2
NAB2 encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains.
Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NGFI-A Binding Protein 2 (NAB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NGFI-A Binding Protein 2 (NAB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NGFI-A Binding Protein 2 (NAB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NGFI-A Binding Protein 2 (NAB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for NGFI-A Binding Protein 2 (NAB2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NGFI-A Binding Protein 2 (NAB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NGFI-A Binding Protein 2 (NAB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NGFI-A Binding Protein 2 (NAB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NGFI-A Binding Protein 2 (NAB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for NGFI-A Binding Protein 2 (NAB2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NGFI-A Binding Protein 2 (NAB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NGFI-A Binding Protein 2 (NAB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NGFI-A Binding Protein 2 (NAB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NGFI-A Binding Protein 2 (NAB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for NGFI-A Binding Protein 2 (NAB2) ELISA Kit Customized Service Offer
  1. "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli."Mol. Cell. Biol. 16:3545-3553(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mader: a novel nuclear protein over expressed in human melanomas."Oncogene 12:963-971(1996) [PubMed] [Europe PMC] [Abstract]
  5. "The Nab2 and Stat6 genes share a common transcription termination region."Genomics 41:33-39(1997) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators."EMBO Rep. 12:1018-1023(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]