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Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9)

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CAS-L; CASL; HEF1; p105; Enhancer Of Filamentation 1; Cas Scaffolding Protein Family Member 2; Cas-Like; CRK-associated substrate-related protein

Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9)
CCC L913
HGNC 7733
MGI 97302
PubMed 24174333
RGD 1306276
UniProt Q14511
Wiki NEDD9
The HEF1 cDNA encodes an 835-amino acid protein containing an N-terminal Src homology (SH) 3 domain and an adjacent domain composed of multiple SH2-binding motifs.
NEDD9 mRNA and protein expression was significantly upregulated in human metastatic melanoma relative to nontransformed melanocytes and benign melanocytic neoplasia, and NEDD9 protein overexpression correlated with metastatic progression in human melanomas. Gain- and loss-of-function studies showed that NEDD9 enhanced invasion in vitro and metastasis in vivo of both normal and transformed human and mouse melanocytes. Furthermore, NEDD9 interacted with FAK (PTK2) to modulate formation of focal contacts to enhance invasion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neural Precursor Cell Expressed, Developmentally Down Regulated 9 (NEDD9) ELISA Kit Customized Service Offer
  1. "Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae."Mol. Cell. Biol. 16:3327-3337(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes."J. Exp. Med. 184:1365-1375(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells."J. Biol. Chem. 272:4230-4236(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates."J. Biol. Chem. 272:29083-29090(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments."Mol. Cell. Biol. 18:3540-3551(1998) [PubMed] [Europe PMC] [Abstract]
  9. "T cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3G."J. Biol. Chem. 273:6446-6451(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Antigens recognized by autologous antibody in patients with renal-cell carcinoma."Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain."Exp. Cell Res. 252:224-235(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Evidence that Dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for Dim1 interactions with hnRNP F and Npw38/PQBP-1."Gene 257:33-43(2000) [PubMed] [Europe PMC] [Abstract]
  13. "MICAL, a novel CasL interacting molecule, associates with vimentin."J. Biol. Chem. 277:14933-14941(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry."Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Phosphorylation of human enhancer of filamentation (HEF1) on serine 369 induces its proteasomal degradation."Biochem. Pharmacol. 78:1017-1025(2009) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Northeast structural genomics consortium target HR5554A."Submitted (FEB-2011) to the PDB data bank