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Semaphorin 5A (SEMA5A)

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SEMAF; SemF; Semaphorin-F; Sema Domain,Immunoglobulin Domain(Ig),Transmembrane Domain(TM)and Short Cytoplasmic Domain 5A

Semaphorin 5A (SEMA5A)
CCC L924
HGNC 10736
MGI 107556
PubMed 15163691
RGD 1308650
UniProt Q13591
Wiki SEMA5A
SEMA5A belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.
The deduced 1,077-amino acid protein contains an N-terminal signal sequence, followed by a semaphorin domain, 7 thrombospondin type-1 repeats, a putative transmembrane domain, and a short cytoplasmic tail. It also has 13 conserved cysteines and a conserved N-glycosylation site. Northern blot analysis of whole mouse embryos detected 2 Semf transcripts at embryonic day 10, and their expression decreased toward birth.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL924Hu01 Recombinant Semaphorin 5A (SEMA5A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL924Hu01 Polyclonal Antibody to Semaphorin 5A (SEMA5A) WB; IHC; ICC; IP.
MAL924Hu21 Monoclonal Antibody to Semaphorin 5A (SEMA5A) WB
Assay Kits SEL924Hu ELISA Kit for Semaphorin 5A (SEMA5A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Semaphorin 5A (SEMA5A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Semaphorin 5A (SEMA5A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Semaphorin 5A (SEMA5A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Semaphorin 5A (SEMA5A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Semaphorin 5A (SEMA5A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Semaphorin 5A (SEMA5A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Semaphorin 5A (SEMA5A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Semaphorin 5A (SEMA5A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Semaphorin 5A (SEMA5A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Semaphorin 5A (SEMA5A) ELISA Kit Customized Service Offer
  1. "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval."Biochem. Biophys. Res. Commun. 242:685-691(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Plexin-B3 is a functional receptor for semaphorin 5A."EMBO Rep. 5:710-714(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase."J. Biol. Chem. 285:32436-32445(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis."Microvasc. Res. 79:1-9(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton."Oncogene 31:595-610(2012) [PubMed] [Europe PMC] [Abstract]