Monocyte To Macrophage Differentiation Associated Protein 2 (MMD2)

For a general phenotypic description and a discussion of genetic heterogeneity of Miyoshi muscular dystrophy, Linssen et al. (1998) reported 2 unrelated Dutch families with Miyoshi muscular dystrophy. The phenotype was similar to that described in MMD1, except that the muscle weakness and atrophy were asymmetric from the onset and remained so in 2 affected individuals.In 3 unrelated Dutch families with Miyoshi myopathy, Linssen et al. (1998) excluded linkage to the MMD1 locus on chromosome 2p. Genomewide linkage analysis showed putative linkage to a 23-cM region on chromosome 10p in 2 families. The families were small, and the maximum lod score was 2.578 with 9 markers in this region, including D10S2325. Linssen et al. (1998) noted thatMMD2 was the maximum lod score that could be obtained in these 2 families.