Semaphorin 6C (SEMA6C)

SEMA6C is a member of the semaphorin family of proteins. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration. SEMA6C.1 also has 3 potential N-glycosylation sites. SEMA6C.2 contains 930 amino acids and has a deletion between the extracellular PSI domain and the transmembrane domain. SEMA6C.3 contains 922 amino acids and has an incomplete SEMA domain. Northern blot analysis detected a major transcript of 4.0 kb and a second transcript of 6.0 kb. Expression was high in skeletal muscle, moderate in heart, brain, and kidney, low in liver and placenta, and barely detectable in other tissues examined.