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Neurofascin (NFASC)

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NF; NRCAML

Neurofascin (NFASC)
CCC L939
HGNC 29866
MGI 104753
PubMed 23884033
RGD 620911
UniProt O94856
Wiki Neurofascin
NFASC encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin.
This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL939Hu01 Recombinant Neurofascin (NFASC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL939Hu01 Polyclonal Antibody to Neurofascin (NFASC) WB; IHC; ICC; IP.
MAL939Hu21 Monoclonal Antibody to Neurofascin (NFASC) WB; IHC; ICC; IP.
Assay Kits SEL939Hu ELISA Kit for Neurofascin (NFASC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neurofascin (NFASC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neurofascin (NFASC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurofascin (NFASC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neurofascin (NFASC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurofascin (NFASC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neurofascin (NFASC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neurofascin (NFASC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neurofascin (NFASC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neurofascin (NFASC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neurofascin (NFASC) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Alternative splice variants encoding unstable protein domains exist in the human brain."J. Mol. Biol. 343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling."J. Biol. Chem. 288:26357-26371(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Homophilic adhesion mechanism of neurofascin, a member of the L1 family of neural cell adhesion molecules."J. Biol. Chem. 286:797-805(2011) [PubMed] [Europe PMC] [Abstract]