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Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1)

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NF-ATC; NFAT2; NFATc; NFAT transcription complex cytosolic component

Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1)
CCC L941
HGNC 7775
MGI 102469
PubMed 22457635
UniProt O95644
Wiki NFATC1
NFATC1 is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response.
The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL941Mu01 Recombinant Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) Positive Control; Immunogen; SDS-PAGE; WB.
RPL941Mu02 Recombinant Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL941Mu01 Polyclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) WB; IHC; ICC; IP.
PAL941Mu02 Polyclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) WB; IHC; ICC; IP.
Assay Kits SEL941Mu ELISA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 1 (NFATC1) ELISA Kit Customized Service Offer
  1. "NF-AT components define a family of transcription factors targeted in T-cell activation."Nature 369:497-502(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc."J. Biol. Chem. 271:20914-20921(1996) [PubMed] [Europe PMC] [Abstract]
  3. ErratumJ. Biol. Chem. 271:33705-33705(1996)
  4. "Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells."Immunity 10:261-269(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Alternative splicing and expression of human and mouse NFAT genes."Genomics 92:279-291(2008) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Expression of NFAT-family proteins in normal human T cells."Mol. Cell. Biol. 17:2475-2484(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3."Science 275:1930-1934(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT."Cell 96:611-614(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes."J. Immunol. 162:7294-7301(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization."J. Biol. Chem. 275:3543-3551(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3."J. Biol. Chem. 277:48664-48676(2002) [PubMed] [Europe PMC] [Abstract]
  14. "A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT."Nature 441:646-650(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc."Nature 385:172-176(1997) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of the core NFATC1/DNA complex."Cell 92:687-696(1998) [PubMed] [Europe PMC] [Abstract]
  17. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]