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Nucleolar Protein A2 (NOLA2)

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NHP2; NHP2P; H/ACA ribonucleoprotein complex subunit 2; Nucleolar protein family A member 2; snoRNP protein NHP2

Nucleolar Protein A2 (NOLA2)
CCC L958
HGNC 14377
MGI 1098547
PubMed 10049387
RGD 1309435
UniProt Q9NX24
Wiki NOLA2
NOLA2 is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Two transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein A2 (NOLA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein A2 (NOLA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein A2 (NOLA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein A2 (NOLA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein A2 (NOLA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein A2 (NOLA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein A2 (NOLA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein A2 (NOLA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein A2 (NOLA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein A2 (NOLA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein A2 (NOLA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein A2 (NOLA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein A2 (NOLA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein A2 (NOLA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein A2 (NOLA2) ELISA Kit Customized Service Offer
  1. "Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10."Mol. Cell. Biol. 20:9028-9040(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of the human homologue of the small nucleolar RNA-binding protein NHP2 gene during monocytic differentiation of U937 cells."Biochim. Biophys. Acta 1575:31-39(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Directed proteomic analysis of the human nucleolus."Curr. Biol. 12:1-11(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins."EMBO J. 23:1857-1867(2004) [PubMed] [Europe PMC] [Abstract]
  10. "A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis."Science 323:644-648(2009) [PubMed] [Europe PMC] [Abstract]
  11. "A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58."Mol. Cell 39:618-631(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita."Proc. Natl. Acad. Sci. U.S.A. 105:8073-8078(2008) [PubMed] [Europe PMC] [Abstract]