≡

NADPH Oxidase Activator 1 (NOXA1)

[Edit]

NY-CO-31; SDCCAG31; p51NOX; Serologically Defined Colon Cancer Antigen 31; NCF2-like protein; P67phox-like factor

NADPH Oxidase Activator 1 (NOXA1)
CCC L959
HGNC 10668
MGI 2449980
RGD 1306687
UniProt Q86UR1
NADPH oxidases (NOXs) catalyze the transfer of electrons from NADPH to molecular oxygen to generate reactive oxygen species (ROS). The NOX activator NOXA1 can stimulate both NOX1 and NOX2 (CYBB), but it appears to be more effective in activating NOX1.
The deduced 476-amino acid protein has a calculated molecular mass of 51 kD. It has 4 N-terminal tetratricopeptide repeat motifs, followed by a central activation domain, a PB1 (Phox and Bem1) domain, and a C-terminal SH3 domain. PCR analysis detected abundant p51-NOX expression in pancreas, with weaker expression in liver, kidney, spleen, prostate, small intestine, and colon. p51-NOX expressed in COS-7 cells had an apparent molecular mass of 53 to 54 kD by SDS-PAGE.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADPH Oxidase Activator 1 (NOXA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADPH Oxidase Activator 1 (NOXA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADPH Oxidase Activator 1 (NOXA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADPH Oxidase Activator 1 (NOXA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADPH Oxidase Activator 1 (NOXA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADPH Oxidase Activator 1 (NOXA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADPH Oxidase Activator 1 (NOXA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADPH Oxidase Activator 1 (NOXA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADPH Oxidase Activator 1 (NOXA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADPH Oxidase Activator 1 (NOXA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADPH Oxidase Activator 1 (NOXA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADPH Oxidase Activator 1 (NOXA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADPH Oxidase Activator 1 (NOXA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADPH Oxidase Activator 1 (NOXA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADPH Oxidase Activator 1 (NOXA1) ELISA Kit Customized Service Offer
  1. "Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells."J. Biol. Chem. 278:20006-20012(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases."J. Biol. Chem. 278:25234-25246(2003) [PubMed] [Europe PMC] [Abstract]
  3. "NOX1 NADPH oxidase regulation by the NOXA1 SH3 domain."Free Radic. Biol. Med. 43:384-396(2007) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of human colon cancer antigens recognized by autologous antibodies."Int. J. Cancer 76:652-658(1998) [PubMed] [Europe PMC] [Abstract]
  7. "NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain."J. Biol. Chem. 279:4737-4742(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Nox3 regulation by NOXO1, p47phox, and p67phox."J. Biol. Chem. 279:34250-34255(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to Toll-like receptor 5 signaling in large intestinal epithelial cells."J. Immunol. 172:3051-3058(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators."J. Biol. Chem. 280:23328-23339(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Nox1-dependent reactive oxygen generation is regulated by Rac1."J. Biol. Chem. 281:17718-17726(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1."J. Biol. Chem. 281:21857-21868(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases."Mol. Cell. Biol. 26:2160-2174(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1)."Biochem. Biophys. Res. Commun. 352:560-565(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Regulation of Nox1 activity via PKA-mediated phosphorylation of NoxA1 and 14-3-3 binding."J. Biol. Chem. 282:34787-34800(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity."Sci. Signal. 2:RA54-RA54(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation."Eur. J. Cell Biol. 90:164-171(2011) [PubMed] [Europe PMC] [Abstract]