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Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1)

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MTH1; 7,8-Dihydro-8-Oxoguanine Triphosphatase; 2-hydroxy-dATP diphosphatase; 8-oxo-dGTPase

Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1)
CCC L961
HGNC 8048
MGI 109280
PubMed 7713494
RGD 621080
UniProt P36639
Wiki NUDT1
NUDT1 is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation.
The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleoside Diphosphate Linked Moiety X-Type Motif 1 (NUDT1) ELISA Kit Customized Service Offer
  1. "Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis."J. Biol. Chem. 268:23524-23530(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion."Genomics 24:485-490(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products."J. Biol. Chem. 272:17843-17850(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism."Nucleic Acids Res. 27:4335-4343(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria."J. Biol. Chem. 270:14659-14665(1995) [PubMed] [Europe PMC] [Abstract]
  9. "The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein."J. Biol. Chem. 274:18201-18205(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins."J. Biol. Chem. 274:38251-38259(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP."Nucleic Acids Res. 29:449-454(2001) [PubMed] [Europe PMC] [Abstract]
  12. "A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1."J. Biol. Chem. 277:8579-8587(2002) [PubMed] [Europe PMC] [Abstract]
  13. "An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress."J. Biol. Chem. 278:37965-37973(2003) [PubMed] [Europe PMC] [Abstract]
  14. "The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal."J. Mol. Med. 84:660-670(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2."J. Biol. Chem. 287:21541-21549(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates."J. Biol. Chem. 279:33806-33815(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP."Acta Crystallogr. F 62:1283-1285(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structure of human MTH1 and the 8-oxo-dGMP product complex."FEBS Lett. 585:2617-2621(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Crystal Structure of Human 8-oxo-dGTPase (MTH1)." Submitted (JAN-2011) to the PDB data bank
  21. "Association study of human MTH1 gene polymorphisms with type 1 diabetes mellitus."Endocr. J. 51:493-498(2004) [PubMed] [Europe PMC] [Abstract]
  22. "Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk."Carcinogenesis 27:2448-2454(2006) [PubMed] [Europe PMC] [Abstract]