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Non SMC Element 4 Homolog A (NSMCE4A)

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NSE4A; C10orf86; Non-structural maintenance of chromosomes element 4 homolog A

Non SMC Element 4 Homolog A (NSMCE4A)
CCC L972
HGNC 25935
MGI 1915122
PubMed 15752197
RGD 1309025
UniProt Q9NXX6
Wiki NSMCE4A
Hu et al. (2005) identified NSMCE4A, which is the human ortholog of S. cerevisiae Nse4. The deduced 385-amino acid protein shares 22% similarity with yeast Nse4. Hu et al. (2005) showed that S. cerevisiae Nse4 mutants exhibited growth arrest occurring after S phase and prior to mitosis in a Rad24 checkpoint-dependent manner, and displayed genome instability and sensitivity to DNA damage agents.
Hu et al. (2005) showed that Nse4 is a non-SMC element of the Smc5/Smc6 DNA repair complex.This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Non SMC Element 4 Homolog A (NSMCE4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Non SMC Element 4 Homolog A (NSMCE4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Non SMC Element 4 Homolog A (NSMCE4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Non SMC Element 4 Homolog A (NSMCE4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Non SMC Element 4 Homolog A (NSMCE4A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Non SMC Element 4 Homolog A (NSMCE4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Non SMC Element 4 Homolog A (NSMCE4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Non SMC Element 4 Homolog A (NSMCE4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Non SMC Element 4 Homolog A (NSMCE4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Non SMC Element 4 Homolog A (NSMCE4A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Non SMC Element 4 Homolog A (NSMCE4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Non SMC Element 4 Homolog A (NSMCE4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Non SMC Element 4 Homolog A (NSMCE4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Non SMC Element 4 Homolog A (NSMCE4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Non SMC Element 4 Homolog A (NSMCE4A) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  5. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex."Mol. Cell. Biol. 28:1197-1206(2008) [PubMed] [Europe PMC] [Abstract]
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]