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NUAK Family SNF1 Like Kinase 2 (NUAK2)

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SNARK; OMPHK2; SNF1/AMP Activated Protein Kinase; Omphalocele kinase 2

NUAK Family SNF1 Like Kinase 2 (NUAK2)
CCC L974
HGNC 29558
MGI 1921387
PubMed 21911917
RGD 1359167
UniProt Q9H093
Wiki NUAK2
NUAK2, which resides at 1q32, is a member of the SNF1/AMP kinase (AMPK) family (serine/threonine kinases) that is regulated by the putative tumor suppressor LKB1 (20–23) and also by death receptor signaling through NF-κB. AMP-related kinases function as critical sensors coupling cellular energy status to cell growth and proliferation by modulating the cell-cycle machinery and, when deregulated, result in cancer development and tumor progression in several cancers of different cell lineages. In melanomas, the LKB1–AMPK signaling pathway is deregulated by oncogenic B-RAF and participates in cancer development. However, the exact mechanisms by which AMP-related kinases participate in cancer development and tumor progression remain unknown.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NUAK Family SNF1 Like Kinase 2 (NUAK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NUAK Family SNF1 Like Kinase 2 (NUAK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NUAK Family SNF1 Like Kinase 2 (NUAK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NUAK Family SNF1 Like Kinase 2 (NUAK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for NUAK Family SNF1 Like Kinase 2 (NUAK2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NUAK Family SNF1 Like Kinase 2 (NUAK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NUAK Family SNF1 Like Kinase 2 (NUAK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NUAK Family SNF1 Like Kinase 2 (NUAK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NUAK Family SNF1 Like Kinase 2 (NUAK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for NUAK Family SNF1 Like Kinase 2 (NUAK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NUAK Family SNF1 Like Kinase 2 (NUAK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NUAK Family SNF1 Like Kinase 2 (NUAK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NUAK Family SNF1 Like Kinase 2 (NUAK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NUAK Family SNF1 Like Kinase 2 (NUAK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for NUAK Family SNF1 Like Kinase 2 (NUAK2) ELISA Kit Customized Service Offer
  1. "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."EMBO J. 23:833-843(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].
  5. "Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family."Biochem. Biophys. Res. Commun. 311:156-161(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness."J. Biol. Chem. 279:46742-46747(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of ploidy and senescence by the AMPK-related kinase NUAK1."EMBO J. 29:376-386(2010) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]