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NDC80 Kinetochore Complex Component Homolog (NUF2)

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CDCA1; NUF2R; CT106; Cell Division Cycle Associated 1; Cancer/Testis Antigen 106; Kinetochore protein Nuf2

NDC80 Kinetochore Complex Component Homolog (NUF2)
CCC L976
HGNC 14621
MGI 1914227
PubMed 24129578
RGD 1307952
UniProt Q9BZD4
Wiki NUF2
NUF2 is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation.
The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.disruption of the Nuf2 gene in S. pombe resulted in defects in chromosome segregation and the spindle checkpoint. In particular, the spindles became elongated but without chromosome segregation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NDC80 Kinetochore Complex Component Homolog (NUF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NDC80 Kinetochore Complex Component Homolog (NUF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NDC80 Kinetochore Complex Component Homolog (NUF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NDC80 Kinetochore Complex Component Homolog (NUF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for NDC80 Kinetochore Complex Component Homolog (NUF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NDC80 Kinetochore Complex Component Homolog (NUF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NDC80 Kinetochore Complex Component Homolog (NUF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NDC80 Kinetochore Complex Component Homolog (NUF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NDC80 Kinetochore Complex Component Homolog (NUF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for NDC80 Kinetochore Complex Component Homolog (NUF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NDC80 Kinetochore Complex Component Homolog (NUF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NDC80 Kinetochore Complex Component Homolog (NUF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NDC80 Kinetochore Complex Component Homolog (NUF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NDC80 Kinetochore Complex Component Homolog (NUF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for NDC80 Kinetochore Complex Component Homolog (NUF2) ELISA Kit Customized Service Offer
  1. "A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint."Chromosoma 110:322-334(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation."J. Cell Biol. 152:349-360(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells."J. Cell Biol. 159:549-555(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores."Curr. Biol. 13:2103-2109(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1."Chromosoma 113:1-15(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo."Curr. Biol. 14:611-617(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Timing and checkpoints in the regulation of mitotic progression."Dev. Cell 7:45-60(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of two novel components of the human NDC80 kinetochore complex."J. Biol. Chem. 279:13076-13085(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model."Mol. Cell. Proteomics 3:93-104(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochore."J. Biol. Chem. 280:29088-29095(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Hec1 and Nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites."Mol. Biol. Cell 16:519-531(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment."J. Biol. Chem. 282:21415-21424(2007) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]