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Numb Like Protein (NUMBL)

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CAG3A; CTG3a; NBL; NUMB-R; NUMBR; TNRC23; Numb-related protein

Numb Like Protein (NUMBL)
CCC L977
HGNC 8061
MGI 894702
PubMed 17589506
RGD 1307579
UniProt Q9Y6R0
Wiki NUMBL
The Drosophila 'numb' gene encodes a membrane-associated protein that is predominantly segregated to only 1 of the daughter cells of dividing neural precursors after division, allowing the 2 daughter cells to adopt distinct fates. Studies with mouse Numb in dividing ventricular cells during cortical neurogenesis suggested that Numb suppresses Notch1 activity in the daughter cell, allowing it to remain as a progenitor while the other daughter cell migrates to the cortical plate and terminally differentiates into a neuron.In mouse, the Nbl gene was preferentially expressed in adult and embryonic nervous system. In the developing neocortex, Nbl was expressed in postmitotic neurons in the cortical plate, but not in progenitor cells within the ventricular zone.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Numb Like Protein (NUMBL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Numb Like Protein (NUMBL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Numb Like Protein (NUMBL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Numb Like Protein (NUMBL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Numb Like Protein (NUMBL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Numb Like Protein (NUMBL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Numb Like Protein (NUMBL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Numb Like Protein (NUMBL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Numb Like Protein (NUMBL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Numb Like Protein (NUMBL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Numb Like Protein (NUMBL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Numb Like Protein (NUMBL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Numb Like Protein (NUMBL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Numb Like Protein (NUMBL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Numb Like Protein (NUMBL) ELISA Kit Customized Service Offer
  1. "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module."Genes Dev. 11:2239-2249(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  4. "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation."Cell. Signal. 20:1044-1051(2008) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "NUMBL interacts with TRAF6 and promotes the degradation of TRAF6."Biochem. Biophys. Res. Commun. 392:409-414(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Human numb-like protein, phosphotyrosine interaction domain."Submitted (FEB-2009) to the PDB data bank