≡

Proliferation Associated Protein 2G4 (PA2G4)

[Edit]

EBP1; HG4-1; p38-2G4; Cell cycle protein p38-2G4 homolog; ErbB3-binding protein 1

Proliferation Associated Protein 2G4 (PA2G4)
CCC L980
HGNC 8550
MGI 894684
PubMed 9345902
RGD 1302994
UniProt Q9UQ80
Wiki PA2G4
PA2G4encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing.
This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL980Hu01 Recombinant Proliferation Associated Protein 2G4 (PA2G4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL980Hu01 Polyclonal Antibody to Proliferation Associated Protein 2G4 (PA2G4) WB; IHC
MAL980Hu21 Monoclonal Antibody to Proliferation Associated Protein 2G4 (PA2G4) WB; IHC; ICC; IP.
Assay Kits SEL980Hu ELISA Kit for Proliferation Associated Protein 2G4 (PA2G4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferation Associated Protein 2G4 (PA2G4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proliferation Associated Protein 2G4 (PA2G4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proliferation Associated Protein 2G4 (PA2G4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proliferation Associated Protein 2G4 (PA2G4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferation Associated Protein 2G4 (PA2G4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proliferation Associated Protein 2G4 (PA2G4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proliferation Associated Protein 2G4 (PA2G4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proliferation Associated Protein 2G4 (PA2G4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proliferation Associated Protein 2G4 (PA2G4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proliferation Associated Protein 2G4 (PA2G4) ELISA Kit Customized Service Offer
  1. "Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4."Cytogenet. Cell Genet. 78:31-35(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin."Br. J. Cancer 82:683-690(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. , Submitted (JAN-2010) to UniProtKB
  5. , Submitted (DEC-2008) to UniProtKB
  6. "Regulation of the ErbB3 binding protein Ebp1 by protein kinase C."Mol. Cell. Endocrinol. 175:185-191(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation."J. Cell. Physiol. 187:209-217(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases."Nucleic Acids Res. 31:2168-2177(2003) [PubMed] [Europe PMC] [Abstract]
  10. "EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes."Oncogene 23:4454-4465(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling."Br. J. Cancer 92:140-146(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  13. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Ebp1 isoforms distinctively regulate cell survival and differentiation."Proc. Natl. Acad. Sci. U.S.A. 103:10917-10922(2006) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor."Mol. Biol. Cell 20:757-768(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  23. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  25. "The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions."FEBS Lett. 581:4450-4454(2007) [PubMed] [Europe PMC] [Abstract]