Parkin Co Regulated Gene Protein (PACRG)

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GLUP; PARK2CRG; PARK2 Co-Regulated; PARK2 coregulated gene protein; Molecular chaperone/chaperonin-binding protein

Parkin Co Regulated Gene Protein (PACRG)
Parkin coregulated gene protein is a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Parkin Co Regulated Gene Protein (PACRG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Parkin Co Regulated Gene Protein (PACRG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Parkin Co Regulated Gene Protein (PACRG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Parkin Co Regulated Gene Protein (PACRG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Parkin Co Regulated Gene Protein (PACRG) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Parkin Co Regulated Gene Protein (PACRG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Parkin Co Regulated Gene Protein (PACRG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Parkin Co Regulated Gene Protein (PACRG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Parkin Co Regulated Gene Protein (PACRG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Parkin Co Regulated Gene Protein (PACRG) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Parkin Co Regulated Gene Protein (PACRG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Parkin Co Regulated Gene Protein (PACRG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Parkin Co Regulated Gene Protein (PACRG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Parkin Co Regulated Gene Protein (PACRG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Parkin Co Regulated Gene Protein (PACRG) ELISA Kit Customized Service Offer
  1. "Identification of a novel gene linked to parkin via a bi-directional promoter."J. Mol. Biol. 326:11-19(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death."J. Biol. Chem. 278:51901-51910(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Susceptibility to leprosy is associated with PARK2 and PACRG." Nature 427:636-640(2004) [PubMed] [Europe PMC] [Abstract]