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Partner And Localizer Of BRCA2 (PALB2)

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FANCN; Fanconi Anemia,Complementation Group N

Partner And Localizer Of BRCA2 (PALB2)
CCC L983
HGNC 26144
MGI 3040695
PubMed 17200668
RGD 1304759
UniProt Q86YC2
Wiki PALB2
PALB2 encodes a protein that functions in genome maintenance (double strand break repair). This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.
PALB2 was recently identified as a susceptibility gene for familial pancreatic cancer by scientists at the Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins. This paves for the way for developing a new "gene test" for families where pancreatic cancer occurs in multiple family members.Biallelic mutations in PALB2 (also known as FANCN), similar to biallelic BRCA2 mutations, cause Fanconi anemia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Partner And Localizer Of BRCA2 (PALB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Partner And Localizer Of BRCA2 (PALB2) Monoclonal Antibody Customized Service Offer
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Partner And Localizer Of BRCA2 (PALB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Partner And Localizer Of BRCA2 (PALB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Partner And Localizer Of BRCA2 (PALB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Partner And Localizer Of BRCA2 (PALB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Partner And Localizer Of BRCA2 (PALB2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Partner And Localizer Of BRCA2 (PALB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Partner And Localizer Of BRCA2 (PALB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Partner And Localizer Of BRCA2 (PALB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Partner And Localizer Of BRCA2 (PALB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Partner And Localizer Of BRCA2 (PALB2) ELISA Kit Customized Service Offer
  1. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  2. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2."Mol. Cell 22:719-729(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A recurrent mutation in PALB2 in Finnish cancer families." Nature 446:316-319(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Fanconi anemia is associated with a defect in the BRCA2 partner PALB2."Nat. Genet. 39:159-161(2007) [PubMed] [Europe PMC] [Abstract]
  8. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "PALB2 regulates recombinational repair through chromatin association and oligomerization."J. Biol. Chem. 284:18302-18310(2009) [PubMed] [Europe PMC] [Abstract]
  11. "PALB2 is an integral component of the BRCA complex required for homologous recombination repair."Proc. Natl. Acad. Sci. U.S.A. 106:7155-7160(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene."Science 324:217-217(2009) [PubMed] [Europe PMC] [Abstract]
  14. "MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks."J. Cell Sci. 123:1124-1130(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination."Nat. Struct. Mol. Biol. 17:1247-1254(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2."Nat. Struct. Mol. Biol. 17:1255-1259(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair."EMBO Rep. 13:135-141(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Rare germline mutations in PALB2 and breast cancer risk: a population-based study."Hum. Mutat. 33:674-680(2012) [PubMed] [Europe PMC] [Abstract]
  21. "PALB2 self-interaction controls homologous recombination."Nucleic Acids Res. 40:10312-10323(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair."Oncogene 33:4803-4812(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Breast cancer proteins PALB2 and BRCA2 stimulate polymerase eta in recombination-associated DNA synthesis at blocked replication forks."Cell Rep. 6:553-564(2014) [PubMed] [Europe PMC] [Abstract]
  24. "Structural basis for recruitment of BRCA2 by PALB2."EMBO Rep. 10:990-996(2009) [PubMed] [Europe PMC] [Abstract]
  25. "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]
  26. "Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer."Hum. Mutat. 32:E2176-E2188(2011) [PubMed] [Europe PMC] [Abstract]