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Prostate Apoptosis Response 4 (PAR4)

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PAWR; PRKC,Apoptosis,WT1,Regulator

Prostate Apoptosis Response 4 (PAR4)
CCC L991
HGNC 8614
MGI 2149961
PubMed 18660514
RGD 69065
UniProt Q96IZ0
PAR4 is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells.The active domain of the Par-4 protein has been found to confer cancer resistance in transgenic mice without compromising normal viability or aging, and may have therapeutic significance.
WT1 and PAR4 interact specifically both in vitro and in vivo and that this interaction is mediated by the zinc fingers of WT1 and the leucine repeats of PAR4. Functional analyses showed that PAR4 inhibited transcription activated by WT1 and augmented WT1-mediated transcriptional repression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostate Apoptosis Response 4 (PAR4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostate Apoptosis Response 4 (PAR4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostate Apoptosis Response 4 (PAR4) Polyclonal Antibody Customized Service Offer
Assay Kits SEL991Hu ELISA Kit for Prostate Apoptosis Response 4 (PAR4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostate Apoptosis Response 4 (PAR4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostate Apoptosis Response 4 (PAR4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostate Apoptosis Response 4 (PAR4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostate Apoptosis Response 4 (PAR4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostate Apoptosis Response 4 (PAR4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostate Apoptosis Response 4 (PAR4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostate Apoptosis Response 4 (PAR4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostate Apoptosis Response 4 (PAR4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostate Apoptosis Response 4 (PAR4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostate Apoptosis Response 4 (PAR4) ELISA Kit Customized Service Offer
  1. "A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1."Mol. Cell. Biol. 16:6945-6956(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Structural and functional characterization of the upstream regulatory region of the human gene encoding prostate apoptosis response factor-4."Gene 295:109-116(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression."Cancer Res. 61:7255-7263(2001) [PubMed] [Europe PMC] [Abstract]
  5. "p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition."FEBS Lett. 510:57-61(2002) [PubMed] [Europe PMC] [Abstract]
  6. "THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies."Oncogene 22:2432-2442(2003) [PubMed] [Europe PMC] [Abstract]
  7. "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4."J. Biol. Chem. 279:4596-4603(2004) [PubMed] [Europe PMC] [Abstract]
  8. "PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein."J. Biol. Chem. 280:13824-13832(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Structural basis for protein recognition by B30.2/SPRY domains."Mol. Cell 24:967-976(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Apoptosis by Par-4 in cancer and neurodegenerative diseases."Exp. Cell Res. 283:51-66(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Par-4 inducible apoptosis in prostate cancer cells."J. Cell. Biochem. 91:504-512(2004) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]