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Nucleolar Protein A3 (NOLA3)

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NOP10; NOP10P; NOP10 Nucleolar Protein Homolog; Nucleolar protein 10; H/ACA ribonucleoprotein complex subunit 3

Nucleolar Protein A3 (NOLA3)
CCC L995
HGNC 14378
MGI 1913431
PubMed 10049387
RGD 1582780
UniProt Q9NPE3
NOP10is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The deduced 64-amino acid protein could replace the yeast protein in complementation assays.
The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein A3 (NOLA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein A3 (NOLA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein A3 (NOLA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein A3 (NOLA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein A3 (NOLA3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein A3 (NOLA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein A3 (NOLA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein A3 (NOLA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein A3 (NOLA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein A3 (NOLA3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein A3 (NOLA3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein A3 (NOLA3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein A3 (NOLA3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein A3 (NOLA3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein A3 (NOLA3) ELISA Kit Customized Service Offer
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10."Mol. Cell. Biol. 20:9028-9040(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins."EMBO J. 23:1857-1867(2004) [PubMed] [Europe PMC] [Abstract]
  4. "hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase."RNA 12:832-840(2006) [PubMed] [Europe PMC] [Abstract]
  5. "A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis."Science 323:644-648(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10."Hum. Mol. Genet. 16:1619-1629(2007) [PubMed] [Europe PMC] [Abstract]