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Period Circadian Protein 2 (PER2)

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FASPS; Circadian clock protein PERIOD 2

Period Circadian Protein 2 (PER2)
CCC M013
HGNC 8846
MGI 1195265
PubMed 9427249
RGD 61945
UniProt O15055
Wiki PER2

PER2 is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.

A new genetic test from a cheek swab can use Per2 expression levels to tell whether a person is an early morning person or a "night owl". It has also been shown that Per2 and Bmal1 work in opposition to each other.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Period Circadian Protein 2 (PER2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Period Circadian Protein 2 (PER2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Period Circadian Protein 2 (PER2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Period Circadian Protein 2 (PER2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Period Circadian Protein 2 (PER2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Period Circadian Protein 2 (PER2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Period Circadian Protein 2 (PER2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Period Circadian Protein 2 (PER2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Period Circadian Protein 2 (PER2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Period Circadian Protein 2 (PER2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM013Ra01 Recombinant Period Circadian Protein 2 (PER2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAM013Ra21 Monoclonal Antibody to Period Circadian Protein 2 (PER2) WB; IHC; ICC; IP.
PAM013Ra01 Polyclonal Antibody to Period Circadian Protein 2 (PER2) WB; IHC; ICC; IP.
Assay Kits SEM013Ra ELISA Kit for Period Circadian Protein 2 (PER2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2."FEBS Lett. 489:159-165(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei."Neuron 19:1261-1269(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts."Biochem. J. 380:95-103(2004) [PubMed] [Europe PMC] [Abstract]
  6. "PML regulates PER2 nuclear localization and circadian function."EMBO J. 31:1427-1439(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Nucleolar localization and circadian regulation of Per2S, a novel splicing variant of the Period 2 gene."Cell. Mol. Life Sci. 71:2547-2559(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Metabolism and the circadian clock converge."Physiol. Rev. 93:107-135(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular architecture of the mammalian circadian clock."Trends Cell Biol. 24:90-99(2014) [PubMed] [Europe PMC] [Abstract]
  10. "An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome."Science 291:1040-1043(2001) [PubMed] [Europe PMC] [Abstract]
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]