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Period Circadian Protein 3 (PER3)

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GIG13; Cell growth-inhibiting gene 13 protein; Circadian clock protein PERIOD 3

Period Circadian Protein 3 (PER3)
CCC M014
HGNC 8847
MGI 1277134
PubMed 20625127
RGD 621581
UniProt P56645
Wiki PER3
PER3 is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.Per3 rhythmic expression was free-running and was reset by light but not by the developmental delays caused by low temperature. The time of fertilization had no effect on Per3 expression. Per3 mRNA accumulated rhythmically in oocytes and persisted in embryos.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM014Hu01 Recombinant Period Circadian Protein 3 (PER3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Period Circadian Protein 3 (PER3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Period Circadian Protein 3 (PER3) Polyclonal Antibody Customized Service Offer
Assay Kits SEM014Hu ELISA Kit for Period Circadian Protein 3 (PER3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Period Circadian Protein 3 (PER3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Period Circadian Protein 3 (PER3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Period Circadian Protein 3 (PER3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Period Circadian Protein 3 (PER3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Period Circadian Protein 3 (PER3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Period Circadian Protein 3 (PER3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Period Circadian Protein 3 (PER3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Period Circadian Protein 3 (PER3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Period Circadian Protein 3 (PER3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Period Circadian Protein 3 (PER3) ELISA Kit Customized Service Offer
  1. "Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome." EMBO Rep. 2:342-346(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference."Sleep 26:413-415(2003) [PubMed] [Europe PMC] [Abstract]
  4. "SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein."J. Biol. Chem. 280:26863-26872(2005) [PubMed] [Europe PMC] [Abstract]
  5. "PER3 polymorphism predicts sleep structure and waking performance."Curr. Biol. 17:613-618(2007) [PubMed] [Europe PMC] [Abstract]
  6. "PERIOD3, circadian phenotypes, and sleep homeostasis."Sleep Med. Rev. 14:151-160(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Metabolism and the circadian clock converge."Physiol. Rev. 93:107-135(2013) [PubMed] [Europe PMC] [Abstract]
  8. "Sleep ability mediates individual differences in the vulnerability to sleep loss: evidence from a PER3 polymorphism."Cortex 52:47-59(2014) [PubMed] [Europe PMC] [Abstract]
  9. "A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism."FASEB J. 28:1-14(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular architecture of the mammalian circadian clock."Trends Cell Biol. 24:90-99(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference."Neuropsychopharmacology 28:734-739(2003) [PubMed] [Europe PMC] [Abstract]