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Inositol Polyphosphate-5-Phosphatase F (INPP5F)

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SAC2; hSac2; Inositol polyphosphate 5-phosphatase F; Sac domain-containing phosphoinositide 5-phosphatase 2

Inositol Polyphosphate-5-Phosphatase F (INPP5F)
CCC M032
HGNC 17054
MGI 2141867
PubMed 15964807
RGD 1305777
UniProt Q9Y2H2
INPP5F is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants have been observed, but most of them are not thought to be protein-coding.
INPP5F expressed in insect cells showed 5-phosphatase activity against phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and PtdIns(3,4,5)P3, similar to that of type II phosphatases. It did not hydrolyze other inositol phosphates. High activity was maintained between pH 5.5 and 8.0, with maximal activity at pH 6.0. Activity was increased in the presence of Mg(2+) and K+, but not Mn(2+), Ca(2+), or EDTA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Polyphosphate-5-Phosphatase F (INPP5F) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Polyphosphate-5-Phosphatase F (INPP5F) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Polyphosphate-5-Phosphatase F (INPP5F) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Polyphosphate-5-Phosphatase F (INPP5F) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Polyphosphate-5-Phosphatase F (INPP5F) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Polyphosphate-5-Phosphatase F (INPP5F) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Polyphosphate-5-Phosphatase F (INPP5F) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Polyphosphate-5-Phosphatase F (INPP5F) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Polyphosphate-5-Phosphatase F (INPP5F) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Polyphosphate-5-Phosphatase F (INPP5F) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Polyphosphate-5-Phosphatase F (INPP5F) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Polyphosphate-5-Phosphatase F (INPP5F) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Polyphosphate-5-Phosphatase F (INPP5F) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Polyphosphate-5-Phosphatase F (INPP5F) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Polyphosphate-5-Phosphatase F (INPP5F) ELISA Kit Customized Service Offer
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  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
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  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]