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Prolactin Induced Protein (PIP)

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GCDFP15; GPIP4; BRST2; SABP; gp17; Gross cystic disease fluid protein 15; Prolactin-induced protein; Secretory actin-binding protein

Prolactin Induced Protein (PIP)
CCC M035
HGNC 8993
MGI 102696
PubMed 23755096
RGD 70946
UniProt P12273
Wiki PIP
The hormonally responsive prolactin-inducible protein gene is expressed in benign and malignant breast tumor tissues and in some normal exocrine organs such as sweat, salivary, and lacrimal glands.The PIP gene is 7 kb long with 4 exons ranging from 106 bp to 223 bp.
PIP is overexpressed in 80% of primary and metastatic breast cancers, is duplicated in the breast carcinoma cell line T47D. The 2 copies are organized as a large palindrome, lying 'in loco' on one chromosome 7. The FRA7I fragile site lies 2 Mb telomeric to the PIP gene and sets the distal end of the repeated sequence. Breakage at the FRA7I site was repaired by 1 cycle of the breakage--fusion-bridge (BFB) cycle mechanism, resulting in amplification of the PIP gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM035Hu01 Recombinant Prolactin Induced Protein (PIP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM035Hu01 Polyclonal Antibody to Prolactin Induced Protein (PIP) WB; IHC; ICC; IP.
MAM035Hu21 Monoclonal Antibody to Prolactin Induced Protein (PIP) WB; IHC; ICC; IP.
Assay Kits SEM035Hu ELISA Kit for Prolactin Induced Protein (PIP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM035Mu01 Recombinant Prolactin Induced Protein (PIP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM035Mu01 Polyclonal Antibody to Prolactin Induced Protein (PIP) WB; IHC; ICC; IP.
LAM035Mu81 FITC-Linked Polyclonal Antibody to Prolactin Induced Protein (PIP) WB; IHC; ICC; IF.
LAM035Mu71 Biotin-Linked Polyclonal Antibody to Prolactin Induced Protein (PIP) WB; IHC; ICC.
Assay Kits SEM035Mu ELISA Kit for Prolactin Induced Protein (PIP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM035Ra01 Recombinant Prolactin Induced Protein (PIP) Positive Control; Immunogen; SDS-PAGE; WB.
RPM035Ra02 Recombinant Prolactin Induced Protein (PIP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM035Ra01 Polyclonal Antibody to Prolactin Induced Protein (PIP) WB; IHC; ICC; IP.
LAM035Ra81 FITC-Linked Polyclonal Antibody to Prolactin Induced Protein (PIP) WB; IHC; ICC; IF.
LAM035Ra71 Biotin-Linked Polyclonal Antibody to Prolactin Induced Protein (PIP) WB; IHC; ICC.
MAM035Ra21 Monoclonal Antibody to Prolactin Induced Protein (PIP) WB; IHC; ICC; IP.
PAM035Ra02 Polyclonal Antibody to Prolactin Induced Protein (PIP) WB,IHC
Assay Kits SEM035Ra ELISA Kit for Prolactin Induced Protein (PIP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation and sequencing of a cDNA clone for a prolactin-inducible protein (PIP). Regulation of PIP gene expression in the human breast cancer cell line, T-47D."J. Biol. Chem. 262:15236-15241(1987) [PubMed] [Europe PMC] [Abstract]
  2. "The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning, structure and regulation."Mol. Cell. Endocrinol. 80:165-175(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation from a human seminal vesicle library of the cDNA for gp17, a CD4 binding factor."Immunogenetics 46:345-348(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Primary structure of a new actin-binding protein from human seminal plasma."Eur. J. Biochem. 196:743-750(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Origin and evolution of gene for prolactin-induced protein."Gene 383:64-70(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma."J. Mol. Biol. 384:663-672(2008) [PubMed] [Europe PMC] [Abstract]