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Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C)

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B56G; PR61G; Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Gamma Isoform

Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C)
CCC M044
HGNC 9311
MGI 1349475
PubMed 24004697
RGD 1585097
UniProt Q13362
Wiki PPP2R5C
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity.
PPP2R5C encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 2, Regulatory Subunit B' Gamma (PPP2R5C) ELISA Kit Customized Service Offer
  1. "Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle."J. Biol. Chem. 271:5164-5170(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits."Biochem. J. 317:187-194(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a new family of protein phosphatase 2A regulatory subunits."J. Biol. Chem. 270:26123-26128(1995) [PubMed] [Europe PMC] [Abstract]
  8. "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm."J. Biol. Chem. 271:22081-22089(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Antigens recognized by autologous antibody in patients with renal-cell carcinoma."Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
  10. "PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation."Dev. Cell 10:575-585(2006) [PubMed] [Europe PMC] [Abstract]
  11. "B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK."EMBO J. 25:727-738(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Shugoshin collaborates with protein phosphatase 2A to protect cohesin."Nature 441:46-52(2006) [PubMed] [Europe PMC] [Abstract]
  13. "A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55."EMBO J. 26:402-411(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A."Mol. Cell. Biol. 28:448-456(2008) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Structure of the protein phosphatase 2A holoenzyme."Cell 127:1239-1251(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme."Nature 445:53-57(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Structure and function of the PP2A-shugoshin interaction."Mol. Cell 35:426-441(2009) [PubMed] [Europe PMC] [Abstract]
  19. "The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle."Proteins 74:212-221(2009) [PubMed] [Europe PMC] [Abstract]