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Protein Phosphatase 1F (PPM1F)

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CAMKP; CaMKPase; FEM-2; POPX2; hFEM-2; Partner Of PIX 2; Protein fem-2 homolog; Ca(2+)/Calmodulin-Dependent Protein Kinase Phosphatase

Protein Phosphatase 1F (PPM1F)
CCC M056
HGNC 19388
MGI 1918464
PubMed 11864573
RGD 631363
UniProt P49593
Wiki PPM1F
PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases.
Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1F (PPM1F) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1F (PPM1F) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1F (PPM1F) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1F (PPM1F) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1F (PPM1F) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1F (PPM1F) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1F (PPM1F) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1F (PPM1F) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1F (PPM1F) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1F (PPM1F) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 1F (PPM1F) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 1F (PPM1F) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 1F (PPM1F) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 1F (PPM1F) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 1F (PPM1F) ELISA Kit Customized Service Offer
  1. "The Caenorhabditis elegans sex-determining protein fem-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis."J. Biol. Chem. 276:44193-44202(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family."Curr. Biol. 12:317-321(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]