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Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a)

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PKR2; PRKAR2

Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a)
CCC M063
HGNC 9391
MGI 108025
PubMed 24501172
RGD 3393
UniProt P13861
Wiki PRKAR2A
The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans.
PRKAR2a is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of PKA. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, cAMP Dependent Regulatory Type II Alpha (PRKAR2a) ELISA Kit Customized Service Offer
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  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Control of PKA stability and signalling by the RING ligase praja2."Nat. Cell Biol. 13:412-422(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]