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Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b)

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PRKAR1

Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b)
CCC M065
HGNC 9390
MGI 97759
PubMed 24722252
RGD 3392
UniProt P31321
Wiki PRKAR1B
Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. PRKAR1b is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.
BAD is required to assemble the complex, the lack of which results in diminished mitochondria-based glucokinase activity and blunted mitochondrial respiration in response to glucose. Glucose deprivation results in dephosphorylation of BAD, and BAD-dependent cell death.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, cAMP Dependent Regulatory Type I Beta (PRKAR1b) ELISA Kit Customized Service Offer
  1. "Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases."Biochem. Biophys. Res. Commun. 176:166-172(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells."Exp. Cell Res. 214:595-605(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry."Anal. Biochem. 354:279-289(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop."J. Biol. Chem. 285:35910-35918(2010) [PubMed] [Europe PMC] [Abstract]
  10. "A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane."J. Biol. Chem. 287:43789-43797(2012) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]