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Peroxidasin Homolog (PXDN)

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PRG2; PXN; MG50; VPO; VPO1; Melanoma-associated antigen MG50; Vascular peroxidase 1; p53-responsive gene 2 protein

Peroxidasin Homolog (PXDN)
CCC M070
HGNC 14966
MGI 1916925
PubMed 10441517
RGD 1560694
UniProt Q92626
Wiki PXDN
Drosophila peroxidasin is an extracellular matrix-associated peroxidase. It is expressed exclusively in hemocytes derived from head mesoderm at a very early stage of differentiation. Peroxidasin exists as a homotrimer with a unique hybrid structure that combines an enzymatically functional peroxidase domain with motifs that are typically found in extracellular matrix-associated proteins.
It is a secreted protein that contains a secretory recognition sequence at its N terminus. Peroxidasin catalyzes hydrogen peroxide-driven radioiodination, oxidations, and the formation of dityrosine in vitro. It is also thought to function in extracellular matrix consolidation, phagocytosis, and defense.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM070Hu01 Recombinant Peroxidasin Homolog (PXDN) Positive Control; Immunogen; SDS-PAGE; WB.
RPM070Hu02 Recombinant Peroxidasin Homolog (PXDN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM070Hu01 Polyclonal Antibody to Peroxidasin Homolog (PXDN) WB
PAM070Hu02 Polyclonal Antibody to Peroxidasin Homolog (PXDN) WB
LAM070Hu71 Biotin-Linked Polyclonal Antibody to Peroxidasin Homolog (PXDN) WB; IHC; ICC.
MAM070Hu22 Monoclonal Antibody to Peroxidasin Homolog (PXDN) WB; IHC; ICC; IP.
MAM070Hu21 Monoclonal Antibody to Peroxidasin Homolog (PXDN) WB; IHC; ICC
Assay Kits SEM070Hu ELISA Kit for Peroxidasin Homolog (PXDN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peroxidasin Homolog (PXDN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peroxidasin Homolog (PXDN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peroxidasin Homolog (PXDN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peroxidasin Homolog (PXDN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peroxidasin Homolog (PXDN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peroxidasin Homolog (PXDN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peroxidasin Homolog (PXDN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peroxidasin Homolog (PXDN) Polyclonal Antibody Customized Service Offer
Assay Kits SEM070Ra ELISA Kit for Peroxidasin Homolog (PXDN) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene."Biochem. Biophys. Res. Commun. 261:864-869(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A novel melanoma gene (MG50) encoding the interleukin 1 receptor antagonist and six epitopes recognized by human cytolytic T lymphocytes."Cancer Res. 60:6448-6456(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and characterization of VPO1, a new animal heme-containing peroxidase."Free Radic. Biol. Med. 45:1682-1694(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  7. Unpublished observations (FEB-2008)
  8. "Peroxidasin is secreted and incorporated into the extracellular matrix of myofibroblasts and fibrotic kidney."Am. J. Pathol. 175:725-735(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Homozygous mutations in PXDN cause congenital cataract, corneal opacity, and developmental glaucoma." Am. J. Hum. Genet. 89:464-473(2011) [PubMed] [Europe PMC] [Abstract]