Ribosomal Protein S6 Kinase Beta 2 (RPS6Kb2)

RPS6Kb2 encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.

The deduced proteins contain 495 and 482 amino acids, respectively, and are identical except for the 13-amino acid N-terminal extension in beta-1, which contains a putative nuclear localization signal. The variants could be expressed through alternative mRNA splicing or through the use of an alternative in-frame AUG codon close to the 5-prime end of the cDNA.