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Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2)

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HU-2; RSK; RSK3; S6K-alpha; S6K-alpha2; p90-RSK3; pp90RSK3; 90 kDa ribosomal protein S6 kinase 2; MAP kinase-activated protein kinase 1c

Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2)
CCC M087
HGNC 10431
MGI 1342290
PubMed 16878154
RGD 620676
UniProt Q15349
Wiki RPS6KA2
RPS6Ka2 encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.The deduced 733-amino acid RSK3 protein has 84% and 75% sequence identity with RSK2 (RPS6KA3) and RSK1 (RPS6KA1), respectively. RSK3 has a unique N-terminal sequence which contains a putative bipartite nuclear localization signal. Immunoblot analysis of human cell lysates detected an 83-kD RSK protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal Protein S6 Kinase Alpha 2 (RPS6Ka2) ELISA Kit Customized Service Offer
  1. "RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation."Mol. Cell. Biol. 15:4353-4363(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human rsk isoforms: cloning and characterization of tissue-specific expression."Am. J. Physiol. 266:C351-C359(1994) [PubMed] [Europe PMC] [Abstract]
  6. "90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1."J. Biol. Chem. 274:27168-27176(1999) [PubMed] [Europe PMC] [Abstract]
  7. "RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer."Oncogene 26:683-700(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "The RSK family of kinases: emerging roles in cellular signalling."Nat. Rev. Mol. Cell Biol. 9:747-758(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]