≡

Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5)

[Edit]

MSK1; MSPK1; RLPK; RSKL; RSK-like protein kinase; 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1

Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5)
CCC M090
HGNC 10434
MGI 1920336
PubMed 23110077
RGD 1308336
UniProt O75582
Wiki RPS6KA5
The predicted 802-amino acid MSK1 protein contains 2 protein kinase domains, each of which includes the 11 subdomains characteristic of all protein kinases. MSK1 shares 43% protein sequence identity with the MAPKAP-K1 isoforms. Northern blot analysis indicated that MSK1 was expressed as a 4-kb mRNA in all tissues tested, with the highest levels of expression in brain, muscle, and placenta. Immunoelectron microscopy localized MSK1 to the nucleus.
MSK1 was activated in vitro and in vivo by either ERK or SAPK2 proteins. MSK1, rather than MAPKAP-K1 or MAPKAP-K2/K3, mediates activation of the cAMP response element-binding protein and activating transcription factor-1 by either growth factors or stress signals.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM090Hu01 Recombinant Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal Protein S6 Kinase Alpha 5 (RPS6Ka5) ELISA Kit Customized Service Offer
  1. "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB."EMBO J. 17:4426-4441(1998) [PubMed] [Europe PMC] [Abstract].
  2. "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts."Mol. Cell. Biol. 22:2871-2881(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)."EMBO J. 22:1313-1324(2003) [PubMed] [Europe PMC] [Abstract]
  4. "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14."EMBO J. 22:2788-2797(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway."Exp. Hematol. 31:398-405(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)."Oncogene 22:746-755(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation of histone H2A inhibits transcription on chromatin templates."J. Biol. Chem. 279:21866-21872(2004) [PubMed] [Europe PMC] [Abstract]
  8. "MSK1 activity is controlled by multiple phosphorylation sites."Biochem. J. 387:507-517(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS."Biochem. J. 402:491-501(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition."EMBO J. 27:1682-1693(2008) [PubMed] [Europe PMC] [Abstract]
  11. "MSK activation and physiological roles."Front. Biosci. 13:5866-5879(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "The versatile role of MSKs in transcriptional regulation."Trends Biochem. Sci. 34:311-318(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Development and validation of a method for profiling post-translational modification activities using protein microarrays."PLoS ONE 5:E11332-E11332(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein."Structure 12:1067-1077(2004) [PubMed] [Europe PMC] [Abstract]
  18. "The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1."J. Mol. Biol. 399:41-52(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]