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Ras Related C3 Botulinum Toxin Substrate 2 (Rac2)

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EN-7; Gx; p21-Rac2; Rho Family,Small GTP Binding Protein

Ras Related C3 Botulinum Toxin Substrate 2 (Rac2)
CCC M093
HGNC 9802
MGI 97846
PubMed 15814684
RGD 1307568
UniProt P15153
Wiki RAC2
Members of the RAS superfamily of small GTP-binding proteins appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. The 2 genes encode the C-terminal consensus sequence (CXXX-COOH), which localizes RAS to the inner plasma membrane, and the residues gly12 and ala59, at which sites mutations elicit transforming potential to RAS. RAC2 mRNA displayed relative myeloid tissue selectivity and showed an increase upon differentiation of HL-60 and U937 cells to neutrophil-like and monocyte-like morphology, respectively. Rac2 is selectively expressed in mouse type 1 helper T lymphocytes (Th1). Rac2 induces the interferon-gamma promoter through cooperative interaction of the NF-kappa-B and p38 MAP kinase pathways.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Related C3 Botulinum Toxin Substrate 2 (Rac2) ELISA Kit Customized Service Offer
  1. "Rac, a novel ras-related family of proteins that are botulinum toxin substrates."J. Biol. Chem. 264:16378-16382(1989) [PubMed] [Europe PMC] [Abstract]
  2. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Regulation of the superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins."J. Biol. Chem. 267:10215-10218(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2."Science 254:1512-1515(1991) [PubMed] [Europe PMC] [Abstract]
  7. "A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation."Biochem. Biophys. Res. Commun. 175:451-458(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins."Biochemistry 32:5711-5717(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA."J. Biol. Chem. 266:9786-9794(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins."Biochim. Biophys. Acta 1452:179-187(1999) [PubMed] [Europe PMC] [Abstract]
  11. "The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2."FASEB J. 19:467-469(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI."Nat. Struct. Biol. 7:122-126(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation."Proc. Natl. Acad. Sci. U.S.A. 97:4654-4659(2000) [PubMed] [Europe PMC] [Abstract]
  16. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]