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Ras Associating And Dilute Domain Containing Protein (RADIL)

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Ras Associating And Dilute Domain Containing Protein (RADIL)
CCC M094
HGNC 22226
MGI 2443088
PubMed 17704304
RGD 1306155
UniProt Q96JH8
Wiki RADIL
The transcript contains repetitive elements in its 3-prime UTR, and the deduced 1,114-amino acid protein contains a RAS (HRAS)-association domain, a PDZ domain, and a DIL domain, suggesting it has a role in cell signaling. RT-PCR ELISA detected highest expression in adult brain, spinal cord, testis, and pancreas, moderate expression in heart, lung, skeletal muscle, ovary, and fetal brain, and low expression in spleen, kidney, and adult and fetal liver. Expression was moderate to high in all specific adult brain regions examined, with highest levels in cerebellum.
RADIL protein contains 1,075 amino acids.Knockdown of RADIL in mouse breast epithelial cells or human chondrosarcoma cells resulted in reduced cell adhesion or migration, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Associating And Dilute Domain Containing Protein (RADIL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Associating And Dilute Domain Containing Protein (RADIL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Associating And Dilute Domain Containing Protein (RADIL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Associating And Dilute Domain Containing Protein (RADIL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Associating And Dilute Domain Containing Protein (RADIL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Associating And Dilute Domain Containing Protein (RADIL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Associating And Dilute Domain Containing Protein (RADIL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Associating And Dilute Domain Containing Protein (RADIL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Associating And Dilute Domain Containing Protein (RADIL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Associating And Dilute Domain Containing Protein (RADIL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Associating And Dilute Domain Containing Protein (RADIL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Associating And Dilute Domain Containing Protein (RADIL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Associating And Dilute Domain Containing Protein (RADIL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Associating And Dilute Domain Containing Protein (RADIL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Associating And Dilute Domain Containing Protein (RADIL) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  8. "A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors."Genes Dev. 21:2131-2136(2007) [PubMed] [Europe PMC] [Abstract]
  9. "KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression."J. Cell Biol. 199:951-967(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of RSGI RUH-007, a PDZ domain."Submitted (MAR-2004) to the PDB data bank
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]