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RAP2A, Member Of RAS Oncogene Family (RAP2A)

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K-REV; KREV; RAP2; RbBP-30

RAP2A, Member Of RAS Oncogene Family (RAP2A)
CCC M099
HGNC 9861
MGI 97855
PubMed 20159449
RGD 620590
UniProt P10114
Wiki RAP2A
RAP2A contains domains required for GTP binding and a Ras-like C-terminal motif for posttranslational lipid binding and subsequent anchoring to the plasma membrane. Northern blot analysis of lymphocyte mRNA detected transcripts of 2.2, 2.5, and 4.6 kb.Rap2a and Jnk, as well as their regulators, are expressed at excitatory synapses in rodent brain, and they identified a functional Rap2a signaling pathway in cultured mouse hippocampal CA1 neurons. Synaptic activity and activation of NR2A (GRIN2A)-containing NMDA receptor complexes activated Rap2a, which stimulated Jnk activity. Activation of Rap2a and Jnk led to the removal of Glur1 (GRIA1)- and Glur2 (GRIA2)-containing AMPA receptor complexes, and was essential for depolarization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAP2A, Member Of RAS Oncogene Family (RAP2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAP2A, Member Of RAS Oncogene Family (RAP2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAP2A, Member Of RAS Oncogene Family (RAP2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAP2A, Member Of RAS Oncogene Family (RAP2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAP2A, Member Of RAS Oncogene Family (RAP2A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAP2A, Member Of RAS Oncogene Family (RAP2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAP2A, Member Of RAS Oncogene Family (RAP2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAP2A, Member Of RAS Oncogene Family (RAP2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAP2A, Member Of RAS Oncogene Family (RAP2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAP2A, Member Of RAS Oncogene Family (RAP2A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAP2A, Member Of RAS Oncogene Family (RAP2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAP2A, Member Of RAS Oncogene Family (RAP2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAP2A, Member Of RAS Oncogene Family (RAP2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAP2A, Member Of RAS Oncogene Family (RAP2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAP2A, Member Of RAS Oncogene Family (RAP2A) ELISA Kit Customized Service Offer
  1. "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region."Oncogene 3:201-204(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis."J. Biol. Chem. 266:4315-4321(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated."Biochem. J. 289:349-355(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils."FEBS Lett. 326:209-214(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex."J. Cell Sci. 107:1661-1670(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Interaction of the low-molecular-weight GTP-binding protein rap2 with the platelet cytoskeleton is mediated by direct binding to the actin filaments."J. Cell. Biochem. 75:675-685(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs."J. Biol. Chem. 275:20829-20836(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon."Oncogene 21:8105-8113(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase."J. Biol. Chem. 279:15711-15714(2004) [PubMed] [Europe PMC] [Abstract]
  13. "The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton."J. Biol. Chem. 279:49488-49496(2004) [PubMed] [Europe PMC] [Abstract]
  14. "PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector."Biochem. Biophys. Res. Commun. 329:1046-1052(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Biochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A."Biochem. J. 394:309-315(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation."Biochim. Biophys. Acta 1763:330-335(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway."Genomics 90:249-260(2007) [PubMed] [Europe PMC] [Abstract]
  18. "MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1."Biochem. Biophys. Res. Commun. 377:573-578(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Rap2 function requires palmitoylation and recycling endosome localization."Biochem. Biophys. Res. Commun. 378:732-737(2009) [PubMed] [Europe PMC] [Abstract]
  20. "RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange."FEBS J. 276:4607-4616(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development."Neuron 65:358-372(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Coiled-coil domain containing protein 124 is a novel centrosome and midbody protein that interacts with the ras-guanine nucleotide exchange factor 1B and is involved in cytokinesis."PLoS ONE 8:E69289-E69289(2013) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS."EMBO J. 16:5582-5591(1997) [PubMed] [Europe PMC] [Abstract]
  25. "Structure of the small G protein Rap2 in a non-catalytic complex with GTP."Proteins 37:465-473(1999) [PubMed] [Europe PMC] [Abstract]